When the wife of troubled FBI agent Flynn Carroll goes missing, the trail leads to a shadowy group of international terrorists known as Hunters. To find his wife, Flynn joins forces with the Exo-Terrorism Unit (ETU), a highly classified Homeland Security division charged with stopping the Hunters—terrorists who may not even be human.

A cross between gritty crime drama and sci-fi thriller, Hunters is inspired by Whitley Strieber's best-selling novel, Alien Hunter. The show is about the disappearance of a decorated FBI agent's wife, which leads him to a secret government unit assembled to hunt a group of ruthless terrorists called "Hunters" who do not come from this world.