Brian embarks on his first FBI field assignment when he travels to Quantico to lend his skills to the bureau unit that catches serial killers. However, the trip takes a negative turn when Brian realizes the man he's working with may have put away an innocent person in the career-making case that made him a renowned profiler. Also, Brian tries to stay one step ahead of Rebecca as she comes closer to discovering Senator Morra's connection to NZT.

Limitless, based on Relativity's 2011 Bradley Cooper thriller, picks up where the movie left off and follows Brian Sinclair as he discovers the power of the mysterious drug NZT, and is coerced into using his newfound drug-enhanced abilities to solve weekly cases for the FBI.