When NZT floods the streets of New York City and threatens to become a national epidemic, the FBI partners with the DOJ in a city-wide manhunt to find the lab producing the drug. Also, Brian has trouble adjusting to his new reality when he lacks the resources to continue searching for Piper.

Limitless, based on Relativity's 2011 Bradley Cooper thriller, picks up where the movie left off and follows Brian Sinclair as he discovers the power of the mysterious drug NZT, and is coerced into using his newfound drug-enhanced abilities to solve weekly cases for the FBI.