When a young boy's legs are crushed after being pinned by a car, Malik is determined to use a revolutionary procedure using spider silk to save his limbs, while Zoe lobbies in favor of the safer route of amputation. Also, James, Walter and Talaikha care for Amelia, a young woman in dire need of a liver transplant, but they're puzzled by her resistance when they tell her the donor is her estranged father, Simon.

Pure Genius is a unique medical drama centered around a young Silicon Valley tech billionaire who builds the ultimate cutting-edge hospital that treats only the most rare and insurmountable medical mysteries - at no cost. Lending credibility to this new venture is a maverick surgeon who's the first to discover that his boss's mission is to get bureaucracy out of medicine, use the most forward thinkers in technology, and just save lives - including his own.