Radical treatments are used to help a teenage girl with a rare skin blistering disorder heal in time for her prom; and James is tempted to try his experimental cure on Louis Keating as his GSS condition worsens. On a personal front, Malik is bothered by how James and Zoe relate to each other; at the same time, Zoe has an awkward encounter with James' new crush, Nina.

Pure Genius is a unique medical drama centered around a young Silicon Valley tech billionaire who builds the ultimate cutting-edge hospital that treats only the most rare and insurmountable medical mysteries - at no cost. Lending credibility to this new venture is a maverick surgeon who's the first to discover that his boss's mission is to get bureaucracy out of medicine, use the most forward thinkers in technology, and just save lives - including his own.