Months after her showdown with Charles Siringo, Lizzie Borden has remade herself as a school teacher with a new name in a little town far from Fall River. Seeking peace in anonymity, she's here to be near her sister, Emma, whose reaction to ghastly events of the past has put her in an asylum, under the care of an egotistical but renowned doctor. Lizzie's unaware that two famed gunslingers, Bat Masterson and Tom Horn, are hunting her, driven to learn the fate of their friend, Siringo. When Lizzie helps a victimized student get justice Lizzie-style, she jeopardizes her cover. Worse, Emma makes a startling choice that leaves Lizzie devastated.

The Lizzie Borden Chronicles delivers an intense and fictionalized account of actual events and people surrounding Lizzie's life after her controversial acquittal of the horrific double murder of her father and stepmother in 1892, when the exonerated figure lives a life awash in newfound celebrity filled with scandalous love affairs. But when numerous people close to Lizzie - ranging from her half-brother William, to Broadway luminaries and her business associate/underworld kingpin Mr. Flowers - start to mysteriously die under brutal and strange circumstances, legendary Pinkerton detective Charlie Siringo becomes determined to prove her involvement in their ultimate demise.