Lizzie races to Boston, where Emma has taken refuge in the luxurious home of Adele Trotwood and family, with whom she has a very special connection. Stunned to find a vastly different Emma than the cherished sister she knew, Lizzie unwittingly leads Bat Masterson and Tom Horn directly into their path. However, the Trotwood family proves to be more than your average Boston Brahmins, posing an unexpected challenge to Bat and Tom. Trying to ease tensions, Emma makes an impetuous sacrifice. Lizzie plumbs the depths of her cunning to set out to ambush the gunslingers, and somehow pull the sister she dearly loves back from the abyss.

The Lizzie Borden Chronicles delivers an intense and fictionalized account of actual events and people surrounding Lizzie's life after her controversial acquittal of the horrific double murder of her father and stepmother in 1892, when the exonerated figure lives a life awash in newfound celebrity filled with scandalous love affairs. But when numerous people close to Lizzie - ranging from her half-brother William, to Broadway luminaries and her business associate/underworld kingpin Mr. Flowers - start to mysteriously die under brutal and strange circumstances, legendary Pinkerton detective Charlie Siringo becomes determined to prove her involvement in their ultimate demise.