After her shocking 1893 acquittal for the brutal axe-murders of her parents in Fall River, Massachusetts, Lizzie Borden, ignores the scorn of neighbors to restart her life with her loving older sister, Emma. But renowned Texas Pinkerton agent Charles Siringo shows up determined to find the real truth behind the murders. Their father's ex-business partner, William Almy demands payment of a colossal debt that will bankrupt the sisters. And their shiftless half-brother blackmails them with a dark secret. Lizzie is forced to reappraise the tranquil life she had in mind, and may have to resort to old bloody ways to escape this treacherous bind.

The Lizzie Borden Chronicles delivers an intense and fictionalized account of actual events and people surrounding Lizzie's life after her controversial acquittal of the horrific double murder of her father and stepmother in 1892, when the exonerated figure lives a life awash in newfound celebrity filled with scandalous love affairs. But when numerous people close to Lizzie - ranging from her half-brother William, to Broadway luminaries and her business associate/underworld kingpin Mr. Flowers - start to mysteriously die under brutal and strange circumstances, legendary Pinkerton detective Charlie Siringo becomes determined to prove her involvement in their ultimate demise.