Lizzie and sister Emma break out of their Victorian comfort zone at a debauched bohemian party in New York City. En route home, Lizzie saves a street prostitute from a vicious beating, then gives the scared young woman refuge in her own house. But her charity incurs the wrath of notorious local gangster, Mr. Flowers. A surprise visit by a dashing New York playwright is an amusing distraction as he plies his charm to convince Lizzie to finance his latest work. Pinkerton agent Siringo turns up fresh evidence that further incriminates Lizzie, while a sordid encounter between the hooker and the writer leads Lizzie to mediate the problem in her unique way.

The Lizzie Borden Chronicles delivers an intense and fictionalized account of actual events and people surrounding Lizzie's life after her controversial acquittal of the horrific double murder of her father and stepmother in 1892, when the exonerated figure lives a life awash in newfound celebrity filled with scandalous love affairs. But when numerous people close to Lizzie - ranging from her half-brother William, to Broadway luminaries and her business associate/underworld kingpin Mr. Flowers - start to mysteriously die under brutal and strange circumstances, legendary Pinkerton detective Charlie Siringo becomes determined to prove her involvement in their ultimate demise.