Lizzie plans a lavish housewarming party in her new mansion, when a beautiful New York actress shows up, distressed about her missing brother last seen with Lizzie. Local gangster Mr. Flowers twists the screws on Lizzie in an extortion scheme. Charles Siringo finally meets his anonymous employer, bent on finding the truth about Lizzie, and it doesn't go well. Both Mr. Flowers and Siringo discover too late that their manipulations backfire. Meanwhile, Lizzie's party is a surprising success, and, as a bonus, it infuriates her spiteful neighbors. The only problem is that pesky actress... Ever resourceful, Lizzie finds an opportunity to quash two threats at once.

The Lizzie Borden Chronicles delivers an intense and fictionalized account of actual events and people surrounding Lizzie's life after her controversial acquittal of the horrific double murder of her father and stepmother in 1892, when the exonerated figure lives a life awash in newfound celebrity filled with scandalous love affairs. But when numerous people close to Lizzie - ranging from her half-brother William, to Broadway luminaries and her business associate/underworld kingpin Mr. Flowers - start to mysteriously die under brutal and strange circumstances, legendary Pinkerton detective Charlie Siringo becomes determined to prove her involvement in their ultimate demise.