Pinkerton agent Charles Siringo and stage star Nance O'Keefe, who grows more desperate in her search for her missing brother, have been outplayed by Lizzie. But now they join forces against her. The sleazy new boss of Fall River's underworld, Skipjack, gleefully exploits a lethal secret Lizzie wants hidden. A haughty neighbor incites Lizzie's wrath by mistreating her dog. Worst of all, a romance threatens to come between Lizzie and her beloved her sister, Emma. When Nance uses her wiles to get Skipjack to spill his guts, her frenzied revenge against Lizzie spills blood... just not the blood Nance intended. Meantime, Lizzie mops up her animal-abusing neighbor with a spill of a different sort.

The Lizzie Borden Chronicles delivers an intense and fictionalized account of actual events and people surrounding Lizzie's life after her controversial acquittal of the horrific double murder of her father and stepmother in 1892, when the exonerated figure lives a life awash in newfound celebrity filled with scandalous love affairs. But when numerous people close to Lizzie - ranging from her half-brother William, to Broadway luminaries and her business associate/underworld kingpin Mr. Flowers - start to mysteriously die under brutal and strange circumstances, legendary Pinkerton detective Charlie Siringo becomes determined to prove her involvement in their ultimate demise.